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Anti-eniyan TIMP1 Antibody, Mouse Monoclonal

Apejuwe kukuru:

Ìwẹnumọ Affinity-chromatography Isotype Ko Ṣe ipinnu
Ogun Eya Asin Eya Reactivity Eniyan
Ohun elo Imunoassay Kemiluminescent (CLIA)

Alaye ọja

ọja Tags

Awọn alaye ọja

Ifihan pupopupo
TIMP metallopeptidase inhibitor 1, tun mọ bi TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating aṣayan iṣẹ-ṣiṣe, TPA-S1TPA-induced proteinTissue inhibitor ti metalloproteinases 1, jẹ a adayeba inhibitors ti awọn matrix metalloproteinases a ẹgbẹ ti a ti matrix metalloproteinases. lowo ninu ibajẹ ti matrix extracellular.TIMP-1/TIMP1 wa ninu oyun ati awọn tisọ agba.Awọn ipele ti o ga julọ ni a rii ni egungun, ẹdọfóró, ovary ati ile-ile.Complexes pẹlu metalloproteinases ati irreversibly inactivates wọn nipa abuda si wọn katalitiki sinkii cofactor.TIMP-1/TIMP1 ṣe agbedemeji erythropoiesis in vitro;ṣugbọn, ko dabi IL-3, o jẹ eya-pato, safikun idagbasoke ati iyatọ ti eniyan nikan ati murine erythroid progenitors.Ni afikun si ipa idinamọ rẹ lodi si pupọ julọ awọn MMP ti a mọ, amuaradagba ni anfani lati ṣe agbega ilọsiwaju sẹẹli ni ọpọlọpọ awọn iru sẹẹli, ati pe o tun le ni iṣẹ anti-apoptotic.Itusilẹ ti jiini fifi koodu amuaradagba yii jẹ inducible gaan ni idahun si ọpọlọpọ awọn cytokines ati awọn homonu.Ni afikun, ikosile lati diẹ ninu ṣugbọn kii ṣe gbogbo awọn chromosomes X ti ko ṣiṣẹ ni imọran pe aiṣiṣẹ jiini yii jẹ polymorphic ninu awọn obinrin eniyan.Jiini fifi koodu yii wa laarin intron 6 ti jiini synapsin I ati pe a kọ ni ọna idakeji.Complexes pẹlu metalloproteinases ati irreversibly inactivates wọn nipa abuda si wọn katalitiki sinkii cofactor.TIMP-1/TIMP1 ni a mọ lati ṣiṣẹ lori MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 ati MMP-16.

Awọn ohun-ini

Iṣeduro bata CLIA (Iwa-iṣawari):
1D5-5 ~ 3G11-6
1D12-2 ~ 1G3-7
Mimo > 95% gẹgẹbi ipinnu nipasẹ SDS-PAGE.
Ifipamọ Fọọmù PBS, pH7.4.
Ibi ipamọ Tọju rẹ labẹ awọn ipo ifo ni -20 ℃ si -80 ℃ lori gbigba.
Ṣeduro lati gbe amuaradagba sinu awọn iwọn kekere fun ibi ipamọ to dara julọ.

Ifiwera Idije

Ẹ̀kúnrẹ́rẹ́ (2)
Ẹ̀kúnrẹ́rẹ́ (1)

Bere fun Alaye

Orukọ ọja Ologbo.Rara ID oniye
TIMP1 AB0034-1 1D5-5
AB0034-2 1D12-2
AB0034-3 1G3-7
AB0034-4 3G11-6

Akiyesi: Bioantibody le ṣe adani awọn iwọn fun iwulo rẹ.

Awọn itọkasi

1.Barylski M, Kowalczyk E, Szadkowska I, et al.[Oludaju tissue ti metalloproteinases[J].Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego, 2011, 30 (178): 246-8.

2.Hayakawa T, Yamashita K, Tanzawa K, et al.Iṣẹ ṣiṣe igbega idagbasoke ti inhibitor tissu ti metalloproteinases-1 (TIMP-1) fun ọpọlọpọ awọn sẹẹli A ti ṣee ṣe ifosiwewe idagbasoke tuntun ni omi ara [J].Awọn lẹta FEBS, 1992, 298.

3.Haider DG, Karin S, Gerhard P, et al.Omi ara retinol-abuda amuaradagba 4 dinku lẹhin àdánù làìpẹ ni morbidly sanra koko.[J].Iwe akosile ti Clinical Endocrinology & Metabolism (3): 1168-71.


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