Anti-eniyan TIMP1 Antibody, Mouse Monoclonal
Awọn alaye ọja
Ifihan pupopupo
TIMP metallopeptidase inhibitor 1, tun mọ bi TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating aṣayan iṣẹ-ṣiṣe, TPA-S1TPA-induced proteinTissue inhibitor ti metalloproteinases 1, jẹ a adayeba inhibitors ti awọn matrix metalloproteinases a ẹgbẹ ti a ti matrix metalloproteinases. lowo ninu ibajẹ ti matrix extracellular.TIMP-1/TIMP1 wa ninu oyun ati awọn tisọ agba.Awọn ipele ti o ga julọ ni a rii ni egungun, ẹdọfóró, ovary ati ile-ile.Complexes pẹlu metalloproteinases ati irreversibly inactivates wọn nipa abuda si wọn katalitiki sinkii cofactor.TIMP-1/TIMP1 ṣe agbedemeji erythropoiesis in vitro;ṣugbọn, ko dabi IL-3, o jẹ eya-pato, safikun idagbasoke ati iyatọ ti eniyan nikan ati murine erythroid progenitors.Ni afikun si ipa idinamọ rẹ lodi si pupọ julọ awọn MMP ti a mọ, amuaradagba ni anfani lati ṣe agbega ilọsiwaju sẹẹli ni ọpọlọpọ awọn iru sẹẹli, ati pe o tun le ni iṣẹ anti-apoptotic.Itusilẹ ti jiini fifi koodu amuaradagba yii jẹ inducible gaan ni idahun si ọpọlọpọ awọn cytokines ati awọn homonu.Ni afikun, ikosile lati diẹ ninu ṣugbọn kii ṣe gbogbo awọn chromosomes X ti ko ṣiṣẹ ni imọran pe aiṣiṣẹ jiini yii jẹ polymorphic ninu awọn obinrin eniyan.Jiini fifi koodu yii wa laarin intron 6 ti jiini synapsin I ati pe a kọ ni ọna idakeji.Complexes pẹlu metalloproteinases ati irreversibly inactivates wọn nipa abuda si wọn katalitiki sinkii cofactor.TIMP-1/TIMP1 ni a mọ lati ṣiṣẹ lori MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 ati MMP-16.
Awọn ohun-ini
| Iṣeduro bata | CLIA (Iwa-iṣawari): 1D5-5 ~ 3G11-6 1D12-2 ~ 1G3-7 |
| Mimo | > 95% gẹgẹbi ipinnu nipasẹ SDS-PAGE. |
| Ifipamọ Fọọmù | PBS, pH7.4. |
| Ibi ipamọ | Tọju rẹ labẹ awọn ipo ifo ni -20 ℃ si -80 ℃ lori gbigba. Ṣeduro lati gbe amuaradagba sinu awọn iwọn kekere fun ibi ipamọ to dara julọ. |
Ifiwera Idije
Bere fun Alaye
| Orukọ ọja | Ologbo.Rara | ID oniye |
| TIMP1 | AB0034-1 | 1D5-5 |
| AB0034-2 | 1D12-2 | |
| AB0034-3 | 1G3-7 | |
| AB0034-4 | 3G11-6 |
Akiyesi: Bioantibody le ṣe adani awọn iwọn fun iwulo rẹ.
Awọn itọkasi
1.Barylski M, Kowalczyk E, Szadkowska I, et al.[Oludaju tissue ti metalloproteinases[J].Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego, 2011, 30 (178): 246-8.
2.Hayakawa T, Yamashita K, Tanzawa K, et al.Iṣẹ ṣiṣe igbega idagbasoke ti inhibitor tissu ti metalloproteinases-1 (TIMP-1) fun ọpọlọpọ awọn sẹẹli A ti ṣee ṣe ifosiwewe idagbasoke tuntun ni omi ara [J].Awọn lẹta FEBS, 1992, 298.
3.Haider DG, Karin S, Gerhard P, et al.Omi ara retinol-abuda amuaradagba 4 dinku lẹhin àdánù làìpẹ ni morbidly sanra koko.[J].Iwe akosile ti Clinical Endocrinology & Metabolism (3): 1168-71.
