Anti-eda eniyan MMP-3 Antibody, Mouse Monoclonal
Awọn alaye ọja
Ifihan pupopupo
Matrix metallopeptidase 3 (kikuru bi MMP3) jẹ tun mọ bi stromelysin 1 ati progelatinase.MMP3 jẹ ọmọ ẹgbẹ ti idile matrix metalloproteinase (MMP) ti awọn ọmọ ẹgbẹ rẹ ni ipa ninu didenukole matrix extracellular ni awọn ilana iṣe ti ẹkọ iwulo deede, gẹgẹbi idagbasoke ọmọ inu oyun, ẹda, atunṣe ara, ati awọn ilana aisan pẹlu arthritis ati metastasis.Gẹgẹbi endopeptidase ti o gbẹkẹle zinc, MMP3 ṣe awọn iṣẹ rẹ ni pataki ninu matrix extracellular.Amuaradagba yii ṣiṣẹ nipasẹ awọn inhibitors endogenous meji: alpha2-macroglobulin ati awọn inhibitors tissu ti metalloproteases (TIMPs).MMP3 ṣe ipa aarin ni awọn iru collagen ibaje II, III, IV, IX, ati X, proteoglycans, fibronectin, laminin, ati elastin.Pẹlupẹlu, MMP3 le mu awọn MMPs miiran ṣiṣẹ gẹgẹbi MMP1, MMP7, ati MMP9, ti n ṣe MMP3 pataki ni atunṣe àsopọ asopọ.Imudaniloju ti awọn MMPs ti ni ipa ninu ọpọlọpọ awọn aisan pẹlu arthritis, awọn ọgbẹ onibaje, encephalomyelitis, ati akàn.Sintetiki tabi awọn inhibitors adayeba ti MMPs ja si ni idinamọ ti metastasis, lakoko ti ilana-soke ti MMPs yori si imudara ayabo sẹẹli alakan.
Awọn ohun-ini
| Iṣeduro bata | CLIA (Iwa-iṣawari): 11G11-6 ~ 8A3-9 11G11-6 ~ 5B9-4 |
| Mimo | > 95%, ipinnu nipasẹ SDS-PAGE |
| Ifipamọ Fọọmù | PBS, pH7.4. |
| Ibi ipamọ | Tọju rẹ labẹ awọn ipo ifo ni -20 ℃ si -80 ℃ lori gbigba. Ṣeduro lati gbe amuaradagba sinu awọn iwọn kekere fun ibi ipamọ to dara julọ. |
Ifiwera Idije
Bere fun Alaye
| Orukọ ọja | Ologbo.Rara | ID oniye |
| MMP-3 | AB0025-1 | 11G11-6 |
| AB0025-2 | 8A3-9 | |
| AB0025-3 | 5B9-4 |
Akiyesi: Bioantibody le ṣe adani awọn iwọn fun iwulo rẹ.
Awọn itọkasi
1.Yamanaka H, Matsuda Y, Tanaka M, et al.Serum matrix metalloproteinase 3 gẹgẹbi asọtẹlẹ ti iwọn iparun apapọ lakoko oṣu mẹfa lẹhin wiwọn, ni awọn alaisan ti o ni arthritis rheumatoid tete[J].Arthrits & Rheumatism, 2000, 43 (4): 852-858.
2.Hattori Y, Kida D, Kaneko A.Awọn ipele serum matrix metalloproteinase-3 deede le ṣee lo lati ṣe asọtẹlẹ idariji ile-iwosan ati iṣẹ ṣiṣe ti ara deede ni awọn alaisan ti o ni arthritis rheumatoid[J].Isẹgun Rheumatology, 2018.
