Anti-eda eniyan Her2 Antibody, Mouse Monoclonal
Awọn alaye ọja
Ifihan pupopupo
2 (HER2), ti a tun mọ ni ErbB2, NEU, ati CD340, jẹ iru I membrane glycoprotein ati pe o jẹ ti idile olugba idagba epidermal (EGF).Amuaradagba HER2 ko le di awọn ifosiwewe idagba nitori aini ti agbegbe abuda ligand ti tirẹ ati ni idinamọ ni ilodisi.Bibẹẹkọ, HER2 ṣe agbekalẹ heterodimer kan pẹlu awọn ọmọ ẹgbẹ ẹbi olugba EGF miiran ti o ni asopọ ligand, nitorinaa ṣeduro isopọpọ ligand ati mu imuṣiṣẹ-alaja kinase ti awọn ohun elo isalẹ.HER2 ṣe ipa pataki ninu idagbasoke, ilọsiwaju sẹẹli ati iyatọ.HER2 jiini ti ni ijabọ lati ṣepọ pẹlu aiṣedeede ati asọtẹlẹ ti ko dara ni ọpọlọpọ awọn carcinomas, pẹlu ọmu, prostate, ovarian, awọn aarun ẹdọfóró ati bẹbẹ lọ.
Awọn ohun-ini
| Iṣeduro bata | CLIA (Iwa-iṣawari): 14-2~ 15-6 15-6~ 2-10 |
| Mimo | > 95%, ipinnu nipasẹ SDS-PAGE |
| Ifipamọ Fọọmù | PBS, pH7.4. |
| Ibi ipamọ | Tọju rẹ labẹ awọn ipo ifo ni -20 ℃ si -80 ℃ lori gbigba. Ṣeduro lati gbe amuaradagba sinu awọn iwọn kekere fun ibi ipamọ to dara julọ. |
Bere fun Alaye
| Orukọ ọja | Ologbo.Rara | ID oniye |
| Her2 | AB0078-1 | 14-2 |
| AB0078-2 | 15-6 | |
| AB0078-3 | 2-10 |
Akiyesi: Bioantibody le ṣe adani awọn iwọn fun iwulo rẹ.
Awọn itọkasi
1.Krawczyk N, et al.(2009) Ipo HER2 lori awọn sẹẹli tumo ti a tan kaakiri lẹhin ti itọju ailera le yato si ipo HER2 akọkọ lori tumo akọkọ.Anticancer Res.29 (10): 4019-24.
