Igbelaruge Ilana Idagbasoke Oògùn
Ifihan pupopupo
Bioantibody akọkọ-ni-kilasi ati ti o dara ju-ni-kilasi portfolio ti a ṣe lati koju significant egbogi aini pade nipasẹ awọn idagbasoke ti eyọkan ati bi-pato amuaradagba iwosan arannilọwọ, agboguntaisan oògùn conjugates ati macrophage awọn aṣoju safikun fun awọn alaisan ni agbaye.
Itan
Awari ilẹ-ilẹ ti imọ-ẹrọ antibody monoclonal (mAb) nipasẹ Kohler ati Milstein ni ọdun 1975 pese iṣeeṣe ti ṣiṣẹda awọn apo-ara bi kilasi ti awọn itọju ailera (Kohler & Milstein, 1975).Awọn ajẹsara Monoclonal (mAbs) jẹ ọkan ninu awọn iru ẹrọ oogun ti a lo pupọ julọ fun awọn aarun ajakalẹ-arun tabi awọn itọju akàn nitori wọn yan yiyan awọn ọlọjẹ, awọn sẹẹli ajakale, awọn sẹẹli alakan, ati paapaa awọn sẹẹli ajẹsara.Ni ọna yii, wọn ṣe agbedemeji imukuro awọn ohun alumọni ibi-afẹde ati awọn sẹẹli pẹlu awọn ipa ẹgbẹ diẹ ju awọn ọna itọju ailera miiran lọ.Ni pataki, awọn mAbs itọju alakan le ṣe idanimọ awọn ọlọjẹ-dada sẹẹli lori awọn sẹẹli ibi-afẹde ati lẹhinna pa awọn sẹẹli ti a fojusi nipasẹ awọn ọna ṣiṣe lọpọlọpọ.
Eda eniyan dinku pupọ ajẹsara ajẹsara ti agboguntaisan ninu eniyan, ṣiṣe iṣakoso onibaje ṣee ṣe.Iru awọn ilọsiwaju ninu awọn imọ-ẹrọ antibody ti yorisi bugbamu kan ninu idagbasoke awọn mAbs ti itọju ni ọdun mẹwa to kọja.Opo awọn itọsẹ antibody, eyiti o pẹlu awọn ọlọjẹ Fc-fusion, awọn conjugates antibody-oògùn (ADCs), immunocytokines (awọn fusions antibody-cytokine), ati awọn idapọ-enzyme antibody-enzyme, tun ni idagbasoke ati ti iṣowo bi itọju tuntun.
Awọn ipa oogun
Fun awọn alaisan, awọn oogun ifọkansi tuntun tumọ si awọn ipa ẹgbẹ diẹ, awọn ile-iwosan diẹ, ilọsiwaju didara ti igbesi aye, iṣelọpọ pọ si, ati pataki, awọn igbesi aye gigun.Ṣugbọn idagbasoke oogun jẹ ilana gigun, eka.
Itọkasi
Kohler G, Milstein C. Awọn aṣa ti o tẹsiwaju ti awọn sẹẹli ti o dapọ ti o nfi ara pamọ ti pato pato.Iseda.Ọdun 1975;256:495–497.doi: 10.1038/256495a0
Ecker DM, Jones SD, Levine HL.Ọja antibody monoclonal oogun.MAbs.Ọdun 2015;7:9–14.doi: 10.4161/19420862.2015.989042.
Peters C, Brown S. Antibody-oògùn conjugates bi aramada egboogi-akàn chemotherapeutics.Biosci aṣoju 2015; 35 (4): e00225.Atejade 2015 Jul 14. Wa ni https://pubmed.ncbi.nlm.nih.gov/26182432/.Wọle si Oṣu Keje 2020.
Reichert, JM, ati Valge-Archer, VE (2007).Awọn aṣa idagbasoke fun awọn itọju akàn antibody monoclonal.Nat Rev Oògùn Disikov 6, 349-356.
Lazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, et al.(2006).Awọn iyatọ Fc antibody ti a ṣe adaṣe pẹlu iṣẹ imudara imudara.PNAS 103, 4005-4010.
